ZYDELIG® for relapsed follicular lymphoma

ZYDELIG is used when follicular lymphoma returns after treatment with at least 2 prior medicines. ZYDELIG was approved based on response rates. Data are not yet available to show if ZYDELIG improves symptoms or survival. ZYDELIG should not be used as the first medicine to treat people who have been diagnosed with follicular lymphoma, and should not be used in combination with bendamustine and/or Rituxan® (rituximab) to treat people with follicular lymphoma.

Although follicular lymphoma is not curable, your doctor can use different therapies or combinations of therapies to slow the growth of your follicular lymphoma cells and provide you with periods of remission.2,3

How does ZYDELIG work?

ZYDELIG works differently from chemotherapy because it blocks a specific protein in B cells called PPI3Kδ. PI3Kδ sends signals to cancerous B cells, telling them to multiply and helping them survive. ZYDELIG blocks these signals, helping to slow the growth of lymphoma cells.4,5

Proven effective in relapsed follicular lymphoma

ZYDELIG was studied in a clinical trial of6,7:
  • 125
    people with indolent non-Hodgkin lymphoma
  • 72
    of those had relapsed follicular lymphoma7

At least 50% of the people with relapsed follicular lymphoma had been treated with 4 or more prior therapies, and all of them had relapsed within 6 months of being treated with rituximab and chemotherapy.

Of the 72 people with relapsed follicular lymphoma7:
  • 56%
    of people treated with
    ZYDELIG responded
    • 14%
      experienced
      complete remission
    • 42%
      experienced
      partial remission

The safety profile of ZYDELIG has also been established in people with relapsed follicular lymphoma.

View the safety profile

Taking ZYDELIG

Understand your ZYDELIG dose and how to take your medication exactly as prescribed


Learn more

Financial information

Learn more about the financial support offerings that may be available to you while on ZYDELIG® treatment

Call to learn more 1-844-622-2377

References:

  1. ZYDELIG® (idelalisib) [Prescribing Information]. Foster City, CA: Gilead Sciences, Inc.; rev February 2022.
  2. Types of B-cell lymphoma. American Cancer Society website. https://www.cancer.org/cancer/non-hodgkin-lymphoma/about/b-cell-lymphoma.html. Accessed September 15, 2020.
  3. About non-Hodgkin lymphoma. American Cancer Society website. https://www.cancer.org/content/dam/CRC/PDF/Public/8717.00.pdf. Accessed September 15, 2020.
  4. Robak P, Robak T. The emerging role of ibrutinib and idelalisib in the treatment of chronic lymphocytic leukemia. J Hematol Transfus. 2013;1(1):1001.
  5. NCI Dictionary of Cancer Terms. National Cancer Institute website. https://www.cancer.gov/publications/dictionaries/cancer-terms. Accessed September 15, 2020.
  6. Gopal AK, Kahl BS, de Vos S, et al. PI3Kδ inhibition by idelalisib in patients with relapsed indolent lymphoma. N Engl J Med. 2014;370(11):1008-1018.
  7. Salles G, Schuster SJ, de Vos S, et al. Efficacy and safety of idelalisib in patients with relapsed, rituximab- and alkylating agent-refractory follicular lymphoma: a subgroup analysis of a phase 2 study. Haematologica. 2017;102(4):e156-e159.