Last week, my granddaughter asked me to take her fishing. Yesterday, we bought her a rod. Today, she caught her first speckled trout. P.S.I’m living with
relapsed CLL.

 

ZYDELIG is a prescription medicine used to treat adults with Chronic Lymphocytic Leukemia (CLL) in combination with Rituxan® (rituximab) when the disease comes back after prior cancer treatment. It is used in patients who may otherwise be treated with Rituxan alone due to other health concerns.

ZYDELIG should not be used as the first medicine to treat people who have been diagnosed with CLL.

Living with recurrent or relapsed Chronic Lymphocytic Leukemia (CLL) can be challenging. You've already been through at least one treatment regimen, only to have your cancer return. This time around, your doctor has prescribed an alternative treatment approach for your relapsed CLL. ZYDELIG is the first of a new class of drug used in combination with Rituxan® (rituximab) when CLL comes back after prior cancer treatment.

About ZYDELIG

A guide to how ZYDELIG works, talking to your doctor as well as taking and storing it.

Learn More

Safety Profile

Information about managing certain side effects associated with ZYDELIG.

Learn About Possible Side Effects

Accessing ZYDELIG

We are committed to helping patients prescribed ZYDELIG access therapy.

Learn About Access Connect

Patient and Caregiver Resources

Staying informed about your disease and treatment can help you feel more confident in your fight.

View Resources

Important Safety Information

What is the most important information I should know about ZYDELIG?

ZYDELIG can cause serious side effects that can lead to death, including:

  • Liver problems. Abnormal liver blood test results are common during treatment with ZYDELIG. ZYDELIG can cause severe liver problems. Your doctor will do blood tests before and during your treatment with ZYDELIG to check for liver problems. Tell your doctor right away if you get yellowing of your skin or the white part of your eyes (jaundice), dark or brown (tea-colored) urine, pain in the upper right side of your stomach area (abdomen), or bleeding or bruising more easily than normal.
  • Severe diarrhea. Diarrhea is common during treatment with ZYDELIG and can sometimes be severe. Tell your doctor right away if the number of bowel movements you have in a day increases by 6 or more. Ask your doctor about medicines you can take to treat your diarrhea.
  • Lung or breathing problems. Your doctor may do tests to check your lungs if you have breathing problems during treatment with ZYDELIG. Tell your doctor right away if you get new or worsening cough, shortness of breath, difficulty breathing, or wheezing.
  • Infections. Tell your doctor right away if you have a fever or any signs of an infection while taking ZYDELIG.
  • Tear in intestinal wall (perforation). Tell your doctor or get medical help right away if you get new or worsening stomach area (abdomen) pain, chills, fever, nausea, or vomiting.
  • Severe skin reactions. Tell your doctor right away if you get painful sores or ulcers on your skin, lips, or in your mouth; a severe rash with blisters or peeling skin, or a rash with itching.

If you have any of the above serious side effects during treatment with ZYDELIG, your doctor may completely stop your treatment, stop your treatment for a period of time, or change your dose of ZYDELIG.

Who should not take ZYDELIG?

  • Those with a history of serious allergic or skin reactions, as determined by a doctor.

What are the other possible side effects of ZYDELIG?

ZYDELIG can cause serious side effects, including:

  • Serious allergic reaction. Tell your doctor or get medical help right away
  • Low white blood cell count (neutropenia). Neutropenia is common during treatment with ZYDELIG and can sometimes be severe. Your doctor will check your blood counts regularly during treatment with ZYDELIG. Tell your doctor right away if you have a fever or any signs of an infection.

The most common side effects of ZYDELIG when used in combination with Rituxan include pneumonia, fever, feeling tired, rash, cough, and nausea.

What should I tell my doctor before taking ZYDELIG?

  • All of your medical conditions, including if you have liver, lung, or breathing problems or an infection.
  • If you are pregnant or plan to become pregnant. ZYDELIG may harm your unborn baby. Women who are able to become pregnant should use effective birth control (contraception) during treatment with ZYDELIG and for at least 1 month after the last dose of ZYDELIG. Talk to your doctor about birth control methods. Tell your doctor right away if you become pregnant or think you are pregnant during treatment with ZYDELIG.
  • If you are breastfeeding or plan to breastfeed. You and your doctor should decide if you will take ZYDELIG or breastfeed. You should not do both.
  • All the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. ZYDELIG and certain other medicines may affect each other.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1‑800‑FDA‑1088. You can also call 1‑800‑GILEAD‑5 (1‑800‑445‑3235).

Please see full Prescribing Information, including Medication Guide with important warnings.

Gilead, the Gilead logo, ZYDELIG, the ZYDELIG logo, and AccessConnect are trademarks of Gilead Sciences, Inc., or one of its related companies. Other brands noted herein are the property of their respective owners. © 2017 Gilead Sciences, Inc. All rights reserved. ZYDC0182 (02/2017)