ZYDELIG is a PI3K delta inhibitor.
This means ZYDELIG targets PI3K delta,
one of the proteins responsible for leukemia and other cell growth.
ZYDELIG is the first of a new class of drug for patients with
returning or relapsed CLL who may otherwise be treated with Rituxan® (rituximab) alone due to other health concerns.
ZYDELIG is taken in combination with Rituxan®
to treat your relapsed CLL.
ZYDELIG helps stop the growth of your cancer cells
ZYDELIG blocks a signal that helps
cancerous B cells and normal B cells grow and survive.
For many patients, blocking this signal can help slow the cancer from progressing.
Unlike chemotherapy, ZYDELIG initially causes the leukemia blood
cell count to go up as the lymph nodes and other components of CLL go down.
In most patients, this is followed by a decline in the leukemia blood cells over time.
Adding ZYDELIG has been proven effective
In a clinical trial of 220 relapsed CLL patients, 66% of patients treated with
Rituxan® experienced no disease progression at one year,
compared to 13% of patients treated with Rituxan® alone.
The main purpose, or 'primary endpoint,' of this
study was progression-free survival;
meaning how long patients would live without their cancer getting worse.
In this study, patients on ZYDELIG plus
Rituxan® had longer progression-free survival
than those taking Rituxan® alone.
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What is the most important information I should know about ZYDELIG?
ZYDELIG can cause serious side effects that can lead to death, including:
Liver problems. Abnormal liver blood test results are common during treatment with ZYDELIG. ZYDELIG can cause severe liver problems. Your doctor will do blood tests before and during your treatment with ZYDELIG to check for liver problems. Tell your doctor right away if you get yellowing of your skin or the white part of your eyes (jaundice), dark or brown (tea-colored) urine, pain in the upper right side of your stomach area (abdomen), or bleeding or bruising more easily than normal.