Antibody — Antibodies are proteins the body makes to fight back when it notices substances or small particles that shouldn't be there. These may be things that are trying to attack the body (like bacteria, viruses or fungi) or chemicals.
Antibody therapy — Antibody therapy is when antibodies are used as a treatment for diseases such as cancer.
B cell — B cells are a type of white blood cells that form part of the body's natural defense system. Their role in this system is to make antibodies. B cells are sometimes also called B lymphocytes.
Chemotherapy — A type of drug used for the treatment of cancer.
CLL — see Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia — Also called CLL. A type of cancer where the body contains too many "immature" white blood cells (white blood cells are part of the body's natural defense system). These immature white blood cells mostly collect in the blood and bone marrow.
Diarrhea — frequent and watery bowel movements.
Fatigue — Feeling extreme tiredness, and not able to do everyday things due to lack of energy.
LFT — see Liver Function Test
Liver Function Test — Also called LFT. A blood test that helps show how well your liver is working and can identify possible reactions to medications on liver function.
Lymphocytes — A specific type of white blood cell. They play an important part in the body's natural defense system (the 'immune system'). There are two main types of lymphocytes — B lymphocytes (B cells) and T lymphocytes (T cells). Each has a different role in helping to protect the body against things that should not be there.
Molecule — A single 'unit' of a particular substance. Each unit is built in the exact same way, with the same number of 'building blocks' arranged in the same pattern.
Neutropenia — A decrease below normal in the concentration of neutrophils, a type of white blood cell.
PI3-Kinase, or PI3K — Short for phosphatidylinositol 3-kinase. A protein found inside a B cell. It is one of the molecules that play a part in the growth of cancerous B cells and normal B cells. It is the growth of these cells that leads to the development of Chronic Lymphocytic Leukemia (CLL).
PI3-Kinase (PI3K) inhibitor — A chemical substance that slows down, interferes with or reduces the action of PI3-Kinase, or 'PI3K'. ZYDELIG is a PI3-Kinase inhibitor.
Placebo — A treatment that does not contain any active ingredients, but looks the same, and is taken in the same way as a real medicine or treatment.
Primary Endpoint — A primary endpoint is the main goal or purpose of a drug study, to test whether or not a treatment does what it is intended to do.
Progression — In terms of cancer, progression means either the spreading of cancer to other areas of the body or when the cancer becomes worse.
Progression-Free Survival (PFS) — In clinical trials, progression-free survival is the duration of time that patients remain alive without their disease becoming any worse.
Rai Staging System — A ranking system used to categorize the different stages of disease in Chronic Lymphocytic Leukemia (CLL).
Relapse — The return of the signs and symptoms of a patient's disease following a period of improvement.
Side effect — A health problem that occurs when a treatment a patient is taking to help fight their disease also has an unwanted effect on their body.
Stages — The different 'stages' of cancer are a way to describe how far the cancer has spread in the body.
What is the most important information I should know about ZYDELIG?
ZYDELIG can cause serious side effects that can lead to death, including: