ZYDELIG® for relapsed SLL

ZYDELIG is used when SLL returns after treatment with at least 2 prior medicines. ZYDELIG was approved based on response rates. Data are not yet available to show if ZYDELIG improves symptoms or survival. ZYDELIG should not be used as the first medicine to treat people who have been diagnosed with SLL.

Although SLL is not curable, your doctor can use different therapies or combinations of therapies to slow the growth of your SLL cells and provide you with periods of remission.2

How does ZYDELIG work?

ZYDELIG works differently from chemotherapy because it blocks a specific protein in B cells called PI3K delta. PI3K delta sends signals to cancerous B cells telling them to multiply and helping them survive. ZYDELIG blocks these signals, helping to slow the growth of lymphoma cells.3,4

Proven effective in relapsed SLL

ZYDELIG was studied in a clinical trial of5:

  • 125
    people with indolent
    non-Hodgkin lymphoma
  • 26
    of those had
    relapsed SLL

At least 50% of the people with relapsed SLL had been treated with 4 or more prior therapies, and all of them had relapsed within 6 months of being treated with rituximab and chemotherapy.

Of the 26 people with relapsed SLL:

58% of those treated with ZYDELIG responded to treatment

The safety profile of ZYDELIG has also been established in people with relapsed SLL.

View the safety profile
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ZYDELIG patient brochure

The ZYDELIG patient brochure was created to provide tips on managing treatment and information about what to expect with ZYDELIG

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Taking ZYDELIG

Understand your ZYDELIG dose and how to take your medication exactly as prescribed


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Financial information & nurse support

Learn more about the financial information and nurse support offerings that may be available to you while on ZYDELIG treatment

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References:

  1. ZYDELIG® (idelalisib) [prescribing information]. Foster City, CA: Gilead Sciences, Inc.; rev January 2018.
  2. About Non-Hodgkin Lymphoma. American Cancer Society website. https://www.cancer.org/content/dam/CRC/PDF/Public/8717.00.pdf. Accessed October 9, 2017.
  3. Robak P, Robak T. The emerging role of ibrutinib and idelalisib in the treatment of chronic lymphocytic leukemia. J Hematol Transfus. 2013;1(1):1001.
  4. NCI Dictionary of Cancer Terms. National Cancer Institute website. https://www.cancer.gov/publications/dictionaries/cancer-terms. Accessed July 21, 2017.
  5. Gopal AK, Kahl BS, de Vos S, et al. PI3Kδ inhibition by idelalisib in patients with relapsed indolent lymphoma. N Engl J Med. 2014;370(11):1008-1018.