Taking ZYDELIG^®

Actor portrayal

ZYDELIG is a pill you take twice a day¹

150 mg* or

100 mg*

Pills not shown at actual size.

It's important to understand your ZYDELIG (idelalisib) dosage and to take your medication exactly as prescribed.

The recommended dosage for ZYDELIG is 150 mg twice daily. If you experience certain side effects while taking ZYDELIG, your doctor may decide to temporarily or permanently stop ZYDELIG to address the side effect. Once the side effect is resolved, your doctor may restart ZYDELIG at 100 mg twice daily. Of the patients in the clinical trial who stopped and restarted ZYDELIG in order to manage certain side effects, more than half who stopped due to diarrhea or liver toxicity were ultimately able to remain on therapy.^1,2

*Pills and bottles not shown at actual size.

What if you miss a dose of ZYDELIG?¹

Unless your doctor has specifically instructed you to stop taking ZYDELIG, it's important not to miss a dose so you can get the most benefit from your medication as possible. However, if you do miss a dose, there's no need to worry. Get back into your routine by following the directions below:

If you miss a dose within 6 hours, take the missed dose right away and the next dose at your usual time
If it's been more than 6 hours since your missed dose, wait and take the next dose at your usual time

General DOs and DON'Ts¹

DO

Take ZYDELIG exactly as directed by your doctor.

Swallow ZYDELIG whole, with or without food.

Try to take ZYDELIG at the same times every day (setting reminder alarms can help).

Give your doctor and pharmacist a list of all the other medicines you're taking, and inform them of any medication changes.

Store ZYDELIG at 68°F to 86°F (20°C to 30°C), in its original container, and ALWAYS out of reach of children.

Report side effects to your doctor or nurse as soon as possible. You know what is normal for you, so be sure to report anything that seems out of the ordinary at any time while taking ZYDELIG—even if it isn't a side effect listed on this website.

DON'T

Don't change your ZYDELIG dose without first talking to your doctor.

Don't stop taking your ZYDELIG without first talking to your doctor.

Don't take prescription and over-the-counter medicines, vitamins, or herbal supplements without first consulting your doctor. Some of these may interact with ZYDELIG.

Don't use your ZYDELIG if the seal over the bottle opening is broken or missing.

IMPORTANT SAFETY INFORMATION

What is the most important information I should know about ZYDELIG?

ZYDELIG can cause serious side effects that can lead to death, including:

Liver problems. Abnormal liver blood test results are common during treatment with ZYDELIG. ZYDELIG can cause severe liver problems. Your healthcare provider will do blood tests before and during your treatment with ZYDELIG to check for liver problems. Tell your healthcare provider right away if you get yellowing of your skin or the white part of your eyes (jaundice), dark or brown (tea-colored) urine, pain in the upper right side of your stomach area (abdomen), or bleeding or bruising more easily than normal.
Severe diarrhea. Diarrhea is common during treatment with ZYDELIG and can sometimes be severe. Tell your healthcare provider right away if the number of bowel movements you have in a day increases by 6 or more. Ask your healthcare provider about medicines you can take to treat your diarrhea.
Lung problems (pneumonitis). Your healthcare provider may do tests to check your lungs if you have breathing problems during treatment with ZYDELIG. Tell your healthcare provider right away if you get new or worsening cough, shortness of breath, difficulty breathing, or wheezing. Your healthcare provider may treat you with a steroid if you develop lung problems.
Infections. Tell your healthcare provider right away if you have a fever or any signs of an infection while taking ZYDELIG.
Tear in intestinal wall (perforation). Tell your healthcare provider or get medical help right away if you get new or worsening stomach area (abdomen) pain, chills, fever, nausea, or vomiting.
Severe skin reactions. Tell your healthcare provider right away if you get painful sores or ulcers on your skin, lips, or in your mouth; a severe rash with blisters or peeling skin, or itching, or if you have a fever or enlarged lymph nodes.

If you have any of the above serious side effects during treatment with ZYDELIG, your healthcare provider may completely stop your treatment, stop your treatment for a period of time, or change your dose of ZYDELIG.

Who should not take ZYDELIG?

Those who have had a serious allergic reaction to ZYDELIG or have had a severe skin reaction to any drug, as determined by a healthcare provider.

What are the other possible side effects of ZYDELIG?

ZYDELIG can cause serious side effects, including:

Serious allergic reaction, including a severe reaction known as anaphylaxis. Tell your healthcare provider or get medical help right away if you have swelling of the face, lips, or tongue; trouble breathing or swallowing; feeling dizzy or faint; rash or hives; cough; or a fast heartbeat.
Low white blood cell count (neutropenia). Neutropenia is common during treatment with ZYDELIG and can sometimes be severe. Your healthcare provider will check your blood counts regularly during treatment with ZYDELIG. Tell your healthcare provider right away if you have a fever or any signs of an infection.

The most common side effects of ZYDELIG when used in combination with Rituxan include pneumonia, fever, feeling tired, rash, cough, and nausea.

What should I tell my healthcare provider before taking ZYDELIG?

All of your medical conditions, including if you have liver, lung, or breathing problems or an infection.
If you are pregnant or plan to become pregnant. ZYDELIG may harm your unborn baby. Females who are able to become pregnant should have a pregnancy test before starting treatment with ZYDELIG and should use effective birth control (contraception) during treatment with ZYDELIG and for 1 month after the last dose of ZYDELIG. Talk to your healthcare provider about birth control methods. Tell your healthcare provider right away if you become pregnant or think you are pregnant during treatment with ZYDELIG. Males with female partners who are able to become pregnant should use effective birth control during treatment with ZYDELIG and for 3 months after the last dose.
If you are breastfeeding or plan to breastfeed. Do not breastfeed during your treatment with ZYDELIG and for 1 month after the last dose.
All the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. ZYDELIG and certain other medicines may affect each other.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Please see full Prescribing Information, including Medication Guide with important warnings.

INDICATION

What is ZYDELIG?

ZYDELIG (idelalisib) is a prescription medicine used to treat adults with chronic lymphocytic leukemia (CLL), in combination with Rituxan® (rituximab), when CLL comes back after prior cancer treatment and when Rituxan treatment alone may be used due to other health problems.

ZYDELIG should not be used as the first medicine to treat anyone, including people with CLL, small lymphocytic lymphoma (SLL), follicular lymphoma (FL), and other slow growing (indolent) non-Hodgkin lymphomas.

ZYDELIG should not be used in combination with bendamustine and Rituxan, or in combination with Rituxan to treat people with FL, SLL, and other indolent non-Hodgkin lymphomas.

References:

ZYDELIG^® (idelalisib) [Prescribing Information]. Foster City, CA: Gilead Sciences, Inc.; rev February 2022.
Data on file. Gilead Sciences, Inc. 2023.

Taking ZYDELIG^®

ZYDELIG is a pill you take twice a day¹

What if you miss a dose of ZYDELIG?¹

DO

Take ZYDELIG exactly as directed by your doctor.

Swallow ZYDELIG whole, with or without food.

Try to take ZYDELIG at the same times every day (setting reminder alarms can help).

Give your doctor and pharmacist a list of all the other medicines you're taking, and inform them of any medication changes.

Store ZYDELIG at 68°F to 86°F (20°C to 30°C), in its original container, and ALWAYS out of reach of children.

Report side effects to your doctor or nurse as soon as possible. You know what is normal for you, so be sure to report anything that seems out of the ordinary at any time while taking ZYDELIG—even if it isn't a side effect listed on this website.

DON'T

Don't change your ZYDELIG dose without first talking to your doctor.

Don't stop taking your ZYDELIG without first talking to your doctor.

Don't take prescription and over-the-counter medicines, vitamins, or herbal supplements without first consulting your doctor. Some of these may interact with ZYDELIG.

Don't use your ZYDELIG if the seal over the bottle opening is broken or missing.

About ZYDELIG

Tips for managing & reporting certain side effects

Taking ZYDELIG®

ZYDELIG is a pill you take twice a day1

What if you miss a dose of ZYDELIG?1

DO

Take ZYDELIG exactly as directed by your doctor.

Swallow ZYDELIG whole, with or without food.

Try to take ZYDELIG at the same times every day (setting reminder alarms can help).

Give your doctor and pharmacist a list of all the other medicines you're taking, and inform them of any medication changes.

Store ZYDELIG at 68°F to 86°F (20°C to 30°C), in its original container, and ALWAYS out of reach of children.

Report side effects to your doctor or nurse as soon as possible. You know what is normal for you, so be sure to report anything that seems out of the ordinary at any time while taking ZYDELIG—even if it isn't a side effect listed on this website.

DON'T

Don't change your ZYDELIG dose without first talking to your doctor.

Don't stop taking your ZYDELIG without first talking to your doctor.

Don't take prescription and over-the-counter medicines, vitamins, or herbal supplements without first consulting your doctor. Some of these may interact with ZYDELIG.

Don't use your ZYDELIG if the seal over the bottle opening is broken or missing.

About ZYDELIG

Tips for managing & reporting certain side effects

Taking ZYDELIG^®

ZYDELIG is a pill you take twice a day¹

What if you miss a dose of ZYDELIG?¹