Taking ZYDELIG

ZYDELIG is a pill you take twice a day

150mg zydelig pill OR 100mg zydelig pill reduced dose
100mg*

Depending on how you're doing your doctor may prescribe the reduced dose.

If you miss a dose of ZYDELIG

It's important NOT to miss a dose of ZYDELIG. However, if it happens, there's no need to worry. Just get right back into your usual routine by following the directions below:

  • If you miss a dose within 6 hours, take the missed dose right away, and the next dose at your usual time.
  • If it's been more than 6 hours since your missed dose, wait and take the next dose at your usual time.

* not actual size

General Do's and Don'ts

Do

  1. Take ZYDELIG exactly as directed by your doctor.
  2. Take ZYDELIG whole, with or without food.
  3. Try to take ZYDELIG at the same times every day (setting reminder alarms can help).
  4. Give your doctor and pharmacist a list of all the other medicines you're taking, and inform them of any medication changes.
  5. Store ZYDELIG at room temperature, in its original container and ALWAYS out of the reach of children.

Don't

  1. Don't change your ZYDELIG dose, without first talking to your doctor.
  2. Don't stop taking your ZYDELIG without first talking to your doctor.
  3. Don't take prescription, over-the-counter medicines, vitamins or herbal supplements, without first consulting your doctor. Some of these may interact with ZYDELIG.
  4. Don't use your ZYDELIG if the seal over the bottle opening is broken or missing.

Your Partner in Therapy ZYDELIG AccessConnect™

Designed to help you access, afford, and adhere to ZYDELIG therapy.

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Safety Profile

Information about managing certain side effects associated with ZYDELIG.

Learn About Possible Side Effects

Important Safety Information

What is the most important information I should know about ZYDELIG?

ZYDELIG can cause serious side effects that can lead to death, including:

  • Liver problems. Abnormal liver blood test results are common during treatment with ZYDELIG. ZYDELIG can cause severe liver problems. Your doctor will do blood tests before and during your treatment with ZYDELIG to check for liver problems. Tell your doctor right away if you get yellowing of your skin or the white part of your eyes (jaundice), dark or brown (tea-colored) urine, pain in the upper right side of your stomach area (abdomen), or bleeding or bruising more easily than normal.
  • Severe diarrhea. Diarrhea is common during treatment with ZYDELIG and can sometimes be severe. Tell your doctor right away if the number of bowel movements you have in a day increases by 6 or more. Ask your doctor about medicines you can take to treat your diarrhea.
  • Lung or breathing problems. Your doctor may do tests to check your lungs if you have breathing problems during treatment with ZYDELIG. Tell your doctor right away if you get new or worsening cough, shortness of breath, difficulty breathing, or wheezing.
  • Infections. Tell your doctor right away if you have a fever or any signs of an infection while taking ZYDELIG.
  • Tear in intestinal wall (perforation). Tell your doctor or get medical help right away if you get new or worsening stomach area (abdomen) pain, chills, fever, nausea, or vomiting.
  • Severe skin reactions. Tell your doctor right away if you get painful sores or ulcers on your skin, lips, or in your mouth; a severe rash with blisters or peeling skin, or a rash with itching.

If you have any of the above serious side effects during treatment with ZYDELIG, your doctor may completely stop your treatment, stop your treatment for a period of time, or change your dose of ZYDELIG.

Who should not take ZYDELIG?

  • Those with a history of serious allergic or skin reactions, as determined by a doctor.

What are the other possible side effects of ZYDELIG?

ZYDELIG can cause serious side effects, including:

  • Serious allergic reaction. Tell your doctor or get medical help right away
  • Low white blood cell count (neutropenia). Neutropenia is common during treatment with ZYDELIG and can sometimes be severe. Your doctor will check your blood counts regularly during treatment with ZYDELIG. Tell your doctor right away if you have a fever or any signs of an infection.

The most common side effects of ZYDELIG when used in combination with Rituxan include pneumonia, fever, feeling tired, rash, cough, and nausea.

What should I tell my doctor before taking ZYDELIG?

  • All of your medical conditions, including if you have liver, lung, or breathing problems or an infection.
  • If you are pregnant or plan to become pregnant. ZYDELIG may harm your unborn baby. Women who are able to become pregnant should use effective birth control (contraception) during treatment with ZYDELIG and for at least 1 month after the last dose of ZYDELIG. Talk to your doctor about birth control methods. Tell your doctor right away if you become pregnant or think you are pregnant during treatment with ZYDELIG.
  • If you are breastfeeding or plan to breastfeed. You and your doctor should decide if you will take ZYDELIG or breastfeed. You should not do both.
  • All the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. ZYDELIG and certain other medicines may affect each other.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1‑800‑FDA‑1088. You can also call 1‑800‑GILEAD‑5 (1‑800‑445‑3235).

Please see full Prescribing Information, including Medication Guide with important warnings.

Gilead, the Gilead logo, ZYDELIG, the ZYDELIG logo, and AccessConnect are trademarks of Gilead Sciences, Inc., or one of its related companies. Other brands noted herein are the property of their respective owners. © 2017 Gilead Sciences, Inc. All rights reserved. ZYDC0182 (02/2017)