Ann Arbor staging system — a classification system used to describe the extent to which FL has spread. The stages are described by Roman numerals I through IV (1-4). The four stages are further divided into categories (A, B, X and E). This classification is one of the aspects your physician uses to select the right therapy for you.
Antibody — Antibodies are proteins the body makes to fight back when it notices substances or small particles that shouldn't be there. These may be things that are trying to attack the body (like bacteria, viruses or fungi) or chemicals.
Antibody therapy — Antibody therapy is when antibodies are used as a treatment for diseases such as cancer.
B cell — B cells are a type of white blood cells that form part of the body's natural defense system. Their role in this system is to make antibodies. B cells are sometimes also called B lymphocytes.
Chemotherapy — A type of drug used for the treatment of cancer.
Diarrhea — frequent and watery bowel movements.
Fatigue — Feeling extreme tiredness, and not able to do everyday things due to lack of energy.
FL — see Follicular Lymphoma
Follicular Lymphoma — also called FL. A type of cancer that starts in the cells called lymphocytes, which are part of the immune system, and are found in the lymph nodes and other lymphoid tissues (spleen and bone marrow). Lymphomas start in the lymphoid tissue and can spread to other organs.
LFT — see Liver Function Test
Liver Function Test — Also called LFT. A blood test that helps show how well your liver is working and can identify possible reactions to medications on liver function.
Lymphocytes — A specific type of white blood cell. They play an important part in the body's natural defense system (the 'immune system'). There are two main types of lymphocytes — B lymphocytes (B cells) and T lymphocytes (T cells). Each has a different role in helping to protect the body against things that should not be there.
Lymphoid tissue — Found in many places in the body, and includes the lymph nodes, lymphocytes, the spleen and bone marrow.
Molecule — A single 'unit' of a particular substance. Each unit is built in the exact same way, with the same number of 'building blocks' arranged in the same pattern.
Neutropenia — A decrease below normal in the concentration of neutrophils, a type of white blood cell.
PI3-Kinase, or PI3K — Short for phosphatidylinositol 3-kinase. A protein found inside a B cell. It is one of the molecules that play a part in the growth of cancerous B cells and normal B cells. It is the growth of these cells that leads to the development of Follicular B-cell non-Hodgkin Lymphoma (FL).
PI3-Kinase (PI3K) inhibitor — A chemical substance that slows down, interferes with or reduces the action of PI3-Kinase, or 'PI3K'. ZYDELIG is a PI3-Kinase inhibitor.
Placebo — A treatment that does not contain any active ingredients, but looks the same, and is taken in the same way as a real medicine or treatment.
Progression — In terms of cancer, progression means either the spreading of cancer to other areas of the body or when the cancer becomes worse.
Radiation therapy — Treatment with high energy rays, such as x-rays, to kill cancer cells or tumors.
Relapse — The return of the signs and symptoms of a patient's disease following a period of improvement.
Side effect — A health problem that occurs when a treatment a patient is taking to help fight their disease also has an unwanted effect on their body.
Spleen — An organ that is part of the lymphatic system. Located on the left side of the abdomen near the stomach, the spleen makes lymphocytes, filters the blood, stores blood cells, and destroys old blood cells.
Stages — The different 'stages' of cancer are a way to describe how far the cancer has spread in the body.
What is the most important information I should know about ZYDELIG?
ZYDELIG can cause serious side effects that can lead to death, including: