ZYDELIG® dosing

1 pill, twice daily

ZYDELIG offers convenient oral dosing

150 mg PO BID

Recommended starting dose

Image of ZYDELIG® (idelalisib) 150 mg tablets bottle.

100 mg PO BID

Available for managing select AEs

Image of ZYDELIG® (idelalisib) 100 mg tablets bottle.

Pill images and bottles are not actual size.


  • Tablets should be swallowed whole. ZYDELIG can be taken with or without food
  • Continue treatment until disease progression or unacceptable toxicity
  • No dose adjustment of ZYDELIG is necessary for patients with CrCl ≥15 mL/min 2
  • No dose modification is required for lymphocytosis, which has been observed in some patients taking ZYDELIG. This observed lymphocytosis is a pharmacodynamic effect and should not be considered progressive disease in the absence of other clinical findings

Provide PJP prophylaxis during treatment with ZYDELIG

  • Serious or fatal PJP or CMV occurred in <1% of patients treated with ZYDELIG

View additional details and clinical trials experience with 100 mg dose

Go to adverse event monitoring & management

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Dosing guide

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Efficacy in relapsed
follicular lymphoma

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Adverse event monitoring &

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Access Connect®

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AE=adverse event; BID=twice daily; CMV=cytomegalovirus; CrCl=creatinine clearance; PJP=Pneumocystis jirovecii pneumonia; PO=orally.


  1. ZYDELIG® (idelalisib) [prescribing information]. Foster City, CA: Gilead Sciences, Inc.; rev October 2018.
  2. Jin F, Robeson M, Zhou H, Hisoire G, Ramanathan S. The pharmacokinetics and safety of idelalisib in subjects with severe renal impairment. Cancer Chemother Pharmacol. 2015;76(6):1133-1141.