ZYDELIG® mechanism of action

ZYDELIG is the only oral PI3Kδ inhibitor approved in both relapsed/refractory follicular lymphoma and relapsed CLL

ZYDELIG inhibits PI3Kδ, a key driver of multiple B-cell processes

Inhibits multiple signaling pathways, including BCR, CXCR4, and CXCR52-4

Image of how ZYDELIG inhibits multiple signaling pathways, including BCR, CXCR4, and CXCR5.

Inhibits proliferation and induces apoptosis

Image of how ZYDELIG inhibits proliferation and induces apoptosis.

Inhibits homing and adhesion

Image of how ZYDELIG inhibits homing and adhesion.

Mobilizes malignant B cells to the periphery, and may reduce lymph node burden5

Image of how ZYDELIG mobilizes malignant B cells to the periphery, and may reduce lymph node burden.

Effects were observed in cell lines derived from malignant B cells and in primary tumor cells.

Image showing the detailed PI3K delta pathway.

For illustrative purposes only. Not all components of the pathway are illustrated.

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ZYDELIG dosing

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Adverse event monitoring &
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ZYDELIG®
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BCR=B-cell receptor; CLL=chronic lymphocytic leukemia; CXCR=C-X-C chemokine receptor; PI3Kδ=phosphatidylinositol 3-kinase delta.

References:

  1. ZYDELIG® (idelalisib) [prescribing information]. Foster City, CA: Gilead Sciences, Inc.; rev January 2018.
  2. Sharman JP, Coutré SE, Furman RR, et al. Efficacy of idelalisib in CLL subpopulations harboring del(17p) and other adverse prognostic factors: results from a phase 3, randomized, double-blind, placebo-controlled trial. Poster presented at: American Society of Clinical Oncology; May 30-June 3, 2014; Chicago, IL.
  3. Puri KD, Gold MR. Selective inhibitors of phosphoinositide 3-kinase delta: modulators of B-cell function with potential for treating autoimmune inflammatory diseases and B-cell malignancies. Front Immunol. 2012;3:256.
  4. Coutré SE, Barrientos JC, Brown JR, et al. Management of adverse events associated with idelalisib treatment: expert panel opinion. Leuk Lymphoma. 2015;56(10):2779-2786.
  5. Furman RR, Sharman JP, Coutré SE, et al. Idelalisib and rituximab in relapsed chronic lymphocytic leukemia. N Engl J Med. 2014;370(11):997-1007.